Characterisation of the Novel HLA-B*40:587 Allele by Sequencing-Based Typing.

HLA-B*40:587 differs from HLA-B*40:02:01:01 by one nucleotide substitution in codon 275 in exon 5.

Characterisation of the Novel HLA-DRB5*02:02:05 Allele by Sequencing-Based Typing.

HLA-DRB5*02:02:05 differs from HLA-DRB5*02:02:01 by one nucleotide substitution in codon 134 in exon 3.

Inflammasome-targeted therapy might prevent adverse perinatal outcomes of recurrent chronic intervillositis of unknown etiology.

Chronic histiocytic intervillositis of unknown origin (CHI) is a rare placental disorder associated with adverse pregnancy outcomes, frequent recurrence, and a lack of effective preventive strategies. Recent insights indicate a potential link between CHI-associated inflammatory lesions and the inflammasome pathway, suggesting innovative therapeutic avenues. Here we show a potential role of the inflammasome pathway in CHI through comprehensive transcriptomic analysis of grade 2 or 3 histopathologic CHI samples, paired with placental controls.

Characterization of the Novel HLA-A*24:02:169 Allele by Sequencing-Based Typing.

HLA-A*24:02:169 differs from HLA-A*24:02:01:01 by one nucleotide substitution in codon -23 in exon 1.

Characterisation of the novel HLA-DPB1*1618:01 allele by sequencing-based typing.

HLA-DPB1*1618:01 differs from HLA-DPB1*18:01:01:01 by one nucleotide substitution in codon 215 in exon 4.

Characterisation of the novel HLA-DPA1*01:12:03 allele by sequencing-based typing.

HLA-DPA1*01:12:03 differs from HLA-DPA1*01:12:01 by one nucleotide substitution in codon 204 in exon 4.

Characterisation of the novel HLA-A*26:247 allele by sequencing-based typing.

HLA-A*26:247 differs from HLA-A*26:01:01:01 by one nucleotide substitution in codon 245 in exon 4.

Characterisation of the novel HLA-DRB3*02:202 allele by sequencing-based typing.

HLA-DRB3*02:202 differs from DRB3*02:112 by one nucleotide substitution in codon 51 in exon 2.

Characterisation of the novel HLA-C*07:02:151 allele by sequencing-based typing.

HLA-C*07:02:151 differs from HLA-C*07:02:01:01 by one nucleotide substitution in codon 166 in exon 3.

Characterisation of the novel HLA-DRB4*01:182 allele by sequencing-based typing.

HLA-DRB4*01:182 differs from HLA-DRB4*01:03:01:01 by one nucleotide substitution in codon 172 in exon 3.

Characterisation of the novel HLA-DRB4*01:01:12 allele by sequencing-based typing.

HLA-DRB4*01:01:12 differs from HLA-DRB4*01:01:01:01 by one nucleotide substitution in codon 175 in exon 3.

Identification of the novel HLA-DQA1*02:32 allele by next-generation sequencing.

HLA-DQA1*02:32 differs from DQA1*02:01:01 by one nucleotide substitution in codon 210 in exon 4.

Characterization of the novel HLA-DRB1*04:04:20 allele by sequencing-based typing.

HLA-DRB1*04:04:20 differs from HLA-DRB1*04:04:01:04 by one nucleotide substitution in codon 135 in exon 3.

Characterization of the novel HLA-B*51:394Q allele by sequencing-based typing.

HLA-B*51:394Q differs from HLA-B*51:01:01:05 by one nucleotide substitution in codon 339 in exon 7.

Characterization of the novel HLA-C*01:263 allele by sequencing-based typing.

HLA-C*01:263 differs from HLA-C*01:02:01:01 by one nucleotide substitution in codon 98 in exon 3.

Characterization of the novel HLA-C*05:286 allele by sequencing-based typing.

HLA-C*05:286 differs from HLA-C*05:01:01:02 by one nucleotide substitution in codon 283 in exon 5.

Characterization of the novel HLA-B*14:121 allele by sequencing-based typing.

HLA-B*14:121 differs from HLA-B*14:01:01:01 by one nucleotide substitution in codon 319 in exon 6.

Identification of the novel HLA-DRB1*14:253 allele by next-generation sequencing.

HLA-DRB1*14:253 differs from DRB1*14:54:01 by one nucleotide substitution in codon 233 in exon 5.

Identification of the novel HLA-DQB1*03:512 allele by next-generation sequencing.

HLA-DQB1*03:512 differs from DQB1*03:02:01 by one nucleotide substitution in codon 89 in exon 2.

Characterization of the novel HLA-DPB1*1516:01 allele by sequencing-based typing.

HLA-DPB1*1516:01 differs from HLA-DPB1*1229:01 by seven nucleotide substitutions in exon 3.

Characterization of the novel HLA-A*32:177 allele by sequencing-based typing.

HLA-A*32:177 differs from HLA-A*32:01:01:01 by one nucleotide substitution in codon -16 in exon 1.

Characterization of the novel HLA-B*14:122 allele by sequencing-based typing.

HLA-B*14:122 differs from HLA-B*14:02:01:01 by one nucleotide substitution in codon 102 in exon 3.