[The involvement of the respiratory apparatus in leukemias].

In 13 cases of leukemia, different clinical forms showed pleuropulmonary and mediastinal lesions consisting in: mediastinal-hilar adenopathies without the parenchyma involvement (2 cases), with involvement of the pulmonary parenchyma (6 cases) and only one case of pulmonary lesions without adenopathies. In 3 cases leukemia overlapped pulmonary TB, TB sequela (2 cases) or active-evolutive TB (1 case). One case developed to bronchopulmonary neoplasm.

[The simultaneous occurrence of chronic lymphatic leukemia with malignant tumors and the lymphatic reaction caused by malignant growths].

In 352 patients affected with chronic lymphatic leukemia (CLL) the authors simultaneously detected a solid second tumour 22 times (= 6.22%) (6 cancers of the prostrate, 5 cancers of the skin, 4 cancers of the uterus, 2 cancers of the stomach, 2 cancers of the lung, one case of rectal and mamma cancer each and one case of eye sarcoma). In one third of the cases the two malignomas were simultaneously detected, thus it was excluded that the second tumour was induced by the antimitotic treatment of the primary disease.

Translocations (4p+; 6q-) and (12q-; Xp+) in blastic phase of a Ph1-positive chronic myeloid leukemia.

This paper reports a 28-year-old woman with Philadelphia chromosome (Ph1)-positive chronic myeloid leukemia (CML) who developed two marrow cell lines during the blastic phase: one with the translocation (12;X) (q 11;p22) and the other with the translocation (4;6) (p 16;q 25). The literature on involvement of chromosomes 12 and X in translocations and the appearance of 6 q- aberration in CML is summarized. The relationship between the 6 q-aberration and the blast cells with lymphoid appearance in the plastic phase of CML is discussed.

Masked Philadelphia chromosome due to the translocation (1q-;22q +) and small chromosome 19 in a case of acute leukemia.

The case of a 51-year-old female with acute myelomonocytic leukemia (AMMoL) and masked Philadelphia (Ph1) chromosome is reported. The Ph1 resulted from a translocation involving chromosomes 1 and 22, in which a segment of the long arm of one chromosome 1 (1q12----q25) was translocated to the long arm of one chromosome 22 at band 22q11. Additionally, a marker chromosome of unknown origin and deletion of the long arm of one chromosome 19 at band 19q12 were found.

[Minute chromosomes in a case of chronic Ph1-positive myeloid leukemia].

Minute chromosomes (mins) were found in all bone marrow cells in a 62-year-old woman with Ph1 positive chronic myeloid leukemia. The cells had a range of 39 to 50 chromosomes with a mode of 46. The examined metaphases had a variety of numerical and structural chromosome abnormalities, as well as 2 to 6 minute chromosomes.

Incidence and significance of micronuclei in pernicious anemia.

The incidence of micronuclei in bone marrow erythroblasts of patients with pernicious anemia ranged between 0.5-5.6% as compared with the value of 0-0.

Missing X chromosome and ring chromosome 21 in a case of acute myelomonocytic leukemia.

The karyotypic picture of a female patient with acute myelomonocytic leukemia (A.M.M.