Antidepressant-like activity of Sonchus oleraceus in mouse models of immobility tests.

The aim of the present work is to evaluate the putative antidepressant-like effects of hydroethanolic and dichloromethanic extracts from the aerial parts of Sonchus oleraceus (Family Asteraceae) on the performance of male mice in the forced swimming test (FST) and tail suspension test (TST) models predictive of depression. The hydroethanolic and dichloromethanic extracts, both in doses of 30, 100, and 300 mg/kg, were orally administered 1 hour before carrying out the FST or the TST. The immobility time in both the FST and the TST was significantly reduced by acute oral treatment with the extracts (dose range, 100-300 mg/kg), without accompanying changes in ambulation, as assessed in an open-field test.

Antinociceptive effect of the extract of Morus nigra leaves in mice.

Morus nigra has been used to relieve pain in Brazilian folk medicine. This study was conducted to establish the antinociceptive properties of dichloromethane extract from leaves of M. nigra.

Evaluation of the antinociceptive activity of extracts of Sonchus oleraceus L. in mice.

Ethnopharmacological Relevance: Sonchus oleraceus L. has been used to relieve pain in Brazilian folk medicine.

Aim Of The Study: Sonchus oleraceus L.