Publications by authors named "Marina da Matta"
Genomic study of nonsyndromic hearing loss in unaffected individuals: Frequency of pathogenic and likely pathogenic variants in a Brazilian cohort of 2,097 genomes.
Front Genet
August 2022
Article Synopsis
- Hearing loss (HL) is common and poses both clinical and social challenges; a study analyzed whole-genome sequencing data from 2,097 individuals without HL to find variant associations with nonsyndromic hearing loss (NSHL).
- The researchers identified 10.59% of individuals as heterozygotes for sequence variants and a lower percentage for copy-number variants, with certain genes frequently linked to HL.
- A notable finding was that 4.96% of participants had variants tied to autosomal dominant NSHL, suggesting a potential risk for future hearing loss, and the estimated population frequency for affected individuals with autosomal recessive NSHL was about 1 in 2,222.
Analysis of physical activity and plasma levels of soluble CD40 and CD40L in older people with gastrointestinal tract cancer.
Exp Gerontol
April 2022
Regular physical activity prevents and treats cancer patients by assisting and improving the immune system. Co-stimulatory molecules that activate the immune system have been studied in cancer, such as immune checkpoint molecules of the CD40/CD40L pathway. This study aimed to characterize plasma levels of soluble CD40 (sCD40) and CD40 ligand (sCD40L) in older people with gastrointestinal tract (GIT) cancer and associate results with physical activity.
View Article and Find Full Text PDFBackground And Objectives: The prognosis of colorectal cancer (CRC) has improved in the last decades, however, a lower overall survival persists in the elderly. The understanding of immunity changes in the elderly with CRC will allow the emergence of new treatments with higher response rates. 4-1BB and CD40L, an immune checkpoint stimulator, play an important role in T-cell responses and platelets.
View Article and Find Full Text PDFNephrolithiasis is considered a systemic disease. A link has been established between nephrolithiasis, cardiovascular disease (CVD), the metabolic syndrome and atherosclerosis. A significant correlation has been found between the high levels of oxidized low-density lipoprotein (oxLDL) and CVD and atherosclerosis, including coronary and femoral artery disease.
View Article and Find Full Text PDFPregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease compared with control groups.
View Article and Find Full Text PDFArticle Synopsis
- Maternal RhD alloimmunization is an immune response that occurs when a pregnant woman's body recognizes the protein antigens in fetal red blood cells (RBC) as foreign.
- This study analyzed inflammatory chemokine levels in 46 pregnant women, distinguishing between 30 non-alloimmunized and 16 previously alloimmunized women, revealing significantly higher CXCL8 levels and lower CXCL9 and CXCL10 levels in the alloimmunized group.
- The study also identified the RhD status of fetuses, showing that among the alloimmunized mothers, some had anti-D alloantibodies, and further research on serum chemokines and placenta tissue could deepen understanding of the alloim