Surgical trauma and CO2-insufflation impact on adhesion formation in parietal and visceral peritoneal lesions.

CO2-insufflation and electrocoagulation were advanced as causative factors of postsurgical adhesions. We assumed that severe tissue reaction due to electrocoagulation might obscure CO2-insufflation impact on adhesion formation. Therefore, the purpose of this study was to evaluate the effects and interactions of surgical trauma and CO2-insufflation on adhesion formation.

Severe inflammatory reaction induced by peritoneal trauma is the key driving mechanism of postoperative adhesion formation.

Background: Many factors have been put forward as a driving mechanism of surgery-triggered adhesion formation (AF). In this study, we underline the key role of specific surgical trauma related with open surgery (OS) and laparoscopic (LS) conditions in postoperative AF and we aimed to study peritoneal tissue inflammatory reaction (TIR), remodelling specific complications of open surgery (OS) versus LS and subsequently evaluating AF induced by these conditions.

Methods: A prospective randomized study was done in 80 anaesthetised female Wistar rats divided equally into 2 groups.