Full kinetic modeling analysis of [F]fluorocholine Positron Emission Tomography (PET) at initial diagnosis of high-grade glioma.

Purpose: The main objective was to characterize the tracer uptake kinetics of [F]fluoromethylcholine ([F]F-CHO) in high-grade gliomas (HGG) through a full PET kinetic modeling approach. Secondarily, we aimed to explore the relationship between the PET uptake measures and the HGG molecular features.

Materials And Methods: Twenty-four patients with a suspected diagnosis of HGG were prospectively included.

Zigzag vs Helicoidal Gold-Silver 1D Chains: Influence of Subtle Interactions in the Spatial Arrangement of Supramolecular Systems.

The reaction of 4'-(2-thienyl)-2,2':6',2,2''-terpyridine (S-terpy) with the heterometallic complexes [AuAgR(OEt)] (R = CF, CCl) leads to the compounds [{Au(CX)}Ag(S-terpy)] (X = F (), Cl ()). The X-ray diffraction analysis of the complexes shows an alternating disposition of the metals -Au-Ag-Au-Ag- in 1D infinite polymeric chains. Despite the fact of having the same metallic sequence, the spatial arrangement observed for both complexes is very different, since for [{Au(CF)}Ag(S-terpy)] () the metals adopt a zigzag disposition, whereas an helicoidal distribution of the interacting metals is observed for the complex [{Au(CCl)}Ag(S-terpy)] ().

Fast-response flow-based method for evaluating I from biological and hospital waste samples exploiting liquid scintillation detection.

This paper presents a fast and automatic flow-based method to extract I from biological samples and hospital waste, previous to liquid scintillation detection. I is a radionuclide extensively used in Nuclear Medicine due to their beta and gamma disintegrations, whereby hospitals have to manage the associated waste generation. The automatic developed system is based on Lab-On-Valve (LOV) flow-technique exploiting Cl-resin (135 mg per extraction).

Development of a thin layer chromatography method for plasma correction of [F]fluorocholine metabolites in positron emission tomography quantification studies in humans.

Introduction: After its intravenous injection, [F]fluorocholine is oxidized by choline-oxidase into its main plasma metabolite, [F]fluorobetaine. If PET kinetic modeling quantification of [F]fluorocholine uptake is intended, the plasma input time-activity-curve of the parent tracer must be obtained, i.e.

Fully Automated System for Tc Monitoring in Hospital and Urban Residues: A Simple Approach to Waste Management.

Tc is an artificial beta emitter widely used in nuclear medicine for diagnostic tests. A fully automated and rapid system for Tc monitoring is introduced with the aim to improve hospital residues management. This system can also be helpful for controlling urban wastewater.

Automatic in-syringe dispersive liquid-liquid microextraction of ⁹⁹Tc from biological samples and hospital residues prior to liquid scintillation counting.

A new approach exploiting in-syringe dispersive liquid-liquid microextraction (DLLME) for (99)Tc extraction and preconcentration from biological samples, i.e., urine and saliva, and liquid residues from treated patients is presented.

Automatic and simple method for ⁹⁹Tc determination using a selective resin and liquid scintillation detection applied to urine samples.

(99m)Tc (6.0067 h half-life) is an artificial radionuclide largely used in diagnostic medicine. Its daughter (99)Tc is a beta emitter of great concern because of its long half-life (2.