Publications by authors named "Marina V Zaychikova"
Article Synopsis
- * The study introduces a new bacteriophage called vB_KpnP_Klyazma, which was isolated from river water and shows lytic activity against certain bacterial strains with a specific capsule type.
- * A key finding is that the phage's receptor-binding protein, a polysaccharide depolymerase, can modify bacterial capsular polysaccharides, opening potential uses in antimicrobial therapy even if it doesn't kill bacteria directly.
Sequencing and Analysis of Three Mycobacterium tuberculosis Genomes of the B0/N-90 Sublineage.
Microbiol Resour Announc
September 2019
We report the draft genome sequences of three isolates belonging to the B0/N-90 sublineage, EKB34, EKB53, and EKB79. The B0/N-90 sublineage belongs to the prevalent (in Russia) and highly virulent Beijing-B0/W148 sublineage. Isolates EKB34 and EKB79 were obtained from people with immune deficiency.
View Article and Find Full Text PDFMycobacterium tuberculosis is divided into several distinct lineages, and various genetic markers such as IS-elements, VNTR, and SNPs are used for lineage identification. We propose an M. tuberculosis classification approach based on functional polymorphisms in virulence genes.
View Article and Find Full Text PDFVarious genetic markers such as IS-elements, DR-elements, variable number tandem repeats (VNTR), single nucleotide polymorphisms (SNPs) in housekeeping genes and other groups of genes are being used for genotyping. We propose a different approach. We suggest the type II toxin-antitoxin (TA) systems, which play a significant role in the formation of pathogenicity, tolerance and persistence phenotypes, and thus in the survival of Mycobacterium tuberculosis in the host organism at various developmental stages (colonization, infection of macrophages, etc.
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