Publications by authors named "Marina V Antonyuk"
Article Synopsis
- Metabolic syndrome (MetS) is increasingly common globally and is complicated by multiple components, affecting diagnosis and treatment.
- Insulin resistance, primarily triggered by abdominal obesity, plays a central role in MetS development, with lipids, particularly fatty acids (FAs), significantly influencing insulin signaling and inflammation.
- A deficiency in n-3 polyunsaturated fatty acids (PUFAs) and an excess of free fatty acids (FFAs) can lead to issues like impaired glucose transport and oxidative stress, highlighting the need for deeper understanding in order to improve diagnostics and therapies for MetS.
The complexity of the pathogenetic mechanisms of the development of chronic inflammation in asthma determines its heterogeneity and insufficient treatment effectiveness. Nuclear transcription factors, which include peroxisome proliferator-activated receptors, that is, PPARs, play an important role in the regulation of initiation and resolution of the inflammatory process. The ability of PPARs to modulate not only lipid homeostasis but also the activity of the inflammatory response makes them an important pathogenetic target in asthma therapy.
View Article and Find Full Text PDFPurpose: To identify the formation of meteopathic reactions in patients with respiratory diseases under the influence of extreme weather changes in Vladivostok.
Methods: The short-term meteopathic reaction in patients with respiratory diseases to the impact of "Weather Complex", consisting of nine weather parameters, on the day of patient's examination and on 1 and 2 days before the examination, was assessed. 146 acclimatized residents of Vladivostok (29 patients with chronic bronchitis, 51 patients with controlled asthma, 39 patients with uncontrolled asthma and 27 healthy volunteers) were examined.
Background: Environmental pollution, local climatic conditions and their association with the prevalence and exacerbation of asthma are topics of intense current medical investigation.
Materials And Methods: Air pollution in the area of Vladivostock was estimated both by the index of emission volumes of "air gaseous components" (nitrogen oxide and nitrogen dioxide, formaldehyde, hydrogen sulfide, carbon monoxide) in urban atmosphere and by mass spectrometric analysis of precipitates in snow samples. A total of 172 local asthma patients (101 controlled-asthma patients-CAP and 71 non-controlled asthma patients - nCAP) were evaluated with the use of spirometry and body plethysmography.
. Comorbidity of chronic obstructive pulmonary disease (COPD) and asthma (asthma COPD overlap syndrome, ACOS) is a significant problem in pulmonary practice, whose pathogenetic issues are not clarified yet. .
View Article and Find Full Text PDFBackground: Early preclinical diagnosis of COPD is urgent. We proposed that fatty acid composition of red blood cells may serve as a prognostic test for the complications in the chronic respiratory diseases. Fatty acid composition of the erythrocyte membranes in patients with chronic respiratory diseases (chronic bronchitis, CB, and stable chronic obstructive pulmonary disease, COPD) was studied.
View Article and Find Full Text PDFBackground: Disturbances of the fatty acids composition in plasma and red blood cells and eicosanoid synthesis play an important role in the metabolic syndrome (MS) formation.
Methods: The observation group included 61 people with metabolic syndrome (30 patients with MS and normal levels of insulin, 31 people with MS and insulin resistance--IR). The parameters of carbohydrate and lipid metabolism in blood serum were examined.
Background: Modification of fatty acids (FA) composition in erythrocytes lipids as an early indicator of the development of arterial hypertension (AH) and lipid disorders.
Methods: We included 34 patients with arterial hypertension and 11 healthy individuals. Each patient was examined the lipid composition of serum.