Screening of patients with bronchopulmonary diseases using methods of infrared laser photoacoustic spectroscopy and principal component analysis.

A human exhaled air analysis by means of infrared (IR) laser photoacoustic spectroscopy is presented. Eleven healthy nonsmoking volunteers (control group) and seven patients with chronic obstructive pulmonary disease (COPD, target group) were involved in the study. The principal component analysis method was used to select the most informative ranges of the absorption spectra of patients' exhaled air in terms of the separation of the studied groups.

Mid-infrared rotated image singly resonant twisted rectangle optical parametric oscillator based on HgGa(2)S(4) pumped at 1064 nm.

We compare linear, planar ring, and rotated image singly resonant twisted rectangle (RISTRA) type nanosecond optical parametric oscillator cavities using HgGaS nonlinear crystal pumped by 8 ns pulses at 1064 nm from a low beam quality pump source. The input-output characteristics and the output idler beam quality at 6300 nm are compared for two values of the pump beam diameter presenting different cavity Fresnel numbers and magnitudes of the spatial walk-off effect due to birefringence. The RISTRA cavity ensures in all cases a circular output beam profile but is advantageous in terms of beam quality with respect to the planar ring only at a large pump beam diameter.