Angiographic evidence of proliferative retinopathy predicts neuropsychiatric morbidity in diabetic patients.

Introduction: Diabetic retinopathy (DR) is a common vasculopathy categorized as either non-proliferative (NPDR) or proliferative (PDR),characterized by dysfunctional blood-retinal barrier (BRB) and diagnosed using fluorescein angiography (FA). Since the BRB is similar in structure and function to the blood-brain barrier (BBB) and BBB dysfunction plays a key role in the pathogenesis of brain disorders, we hypothesized that PDR, the severe form of DR, is likely to mirror BBB damage and to predict a worse neuropsychiatric outcome.

Methods: A retrospective cohort study was conducted among subjects with diabetes (N=2982) with FA-confirmed NPDR (N=2606) or PDR (N=376).

Intravitreal bevacizumab (avastin) for subfoveal neovascular age-related macular degeneration.

Objective: To report the visual and anatomic outcome of intravitreal bevacizumab (Avastin) injections in the treatment of subfoveal neovascular age-related macular degeneration (AMD).

Methods: Interventional, consecutive, retrospective case series. Sixty-five eyes of 65 patients with subfoveal neovascular age-related macular degeneration (AMD) received three intravitreal bevacizumab (1.

Retinal laser injury during a laser show.

Background: Laser injuries caused by Q-switched lasers are not unusual in the military and laboratories. To our knowledge, only one case of eye injury during a laser show has been reported previously.

Methods: Case series.

Bilateral acute anterior uveitis as a presenting symptom of Mycoplasma pneumoniae infection.

Case Report: To report a case of severe bilateral anterior uveitis associated with Mycoplasma pneumoniae without pulmonary manifestations.

Comments: A healthy 5-year-old girl developed severe bilateral anterior uveitis accompanied by fever, arthralgia, gastrointestinal complaints, and lethargy. Results of laboratory investigations were normal except for high levels of Mycoplasma pneumoniae antibodies.

Punctate inner choroidopathy: resolution after oral steroid treatment and review of the literature.

Case Report: A case of punctate inner choroidopathy (PIC) that resolved after oral steroid treatment is described. The 25-year-old female patient presented with reduced visual acuity of several days duration. Results of fundus examination, fluorescein angiography, and indocyanine green angiography were consistent with PIC with a small choroidal neovascularization lesion nasal to the fovea.

Treatment of subfoveal choroidal neovascularization secondary to choroidal nevus using photodynamic therapy.

A 52-year-old man sought treatment for decreased vision in his right eye for 3 weeks. Visual acuity was 20/120. Examination revealed an elevated choroidal nevus at the posterior pole.

Attempted bilateral manual enucleation (gouging) during a physical assault.

Objective: To report a rare, severe case of partial traumatic bilateral enucleation and its assessment and management.

Design: Case report and literature review.

Methods: A report of clinical and imaging findings, surgical procedure, medical treatment, and final outcome.