Publications by authors named "Marina Ruzic"
Article Synopsis
- Methylglyoxal (MG) is a reactive compound produced by microorganisms and host cells that must be detoxified quickly to protect macromolecules from damage.
- Strains of a certain pathogen are more sensitive to MG due to mutations that impair the LasR protein, leading to disruptions in metabolic regulation through the CbrAB system.
- The study suggests that lower levels of reduced glutathione (GSH) in these LasR- strains make them more vulnerable to MG, and adding GSH can help mitigate this sensitivity.
Article Synopsis
- Cystic fibrosis (CF) patients often suffer from chronic lung infections caused by bacteria and fungi, leading to research on how these organisms evolve in response to their environment.
- Whole-genome sequencing revealed that individuals with CF developed mutations in the gene related to the mitochondrial iron transporter Mrs4, which resulted in a loss of function.
- The mutations allowed fungi to enhance their iron acquisition mechanisms, suggesting that these adaptations help them thrive in the iron-restricted conditions of CF lung infections, potentially guiding future therapeutic strategies.
The genetic disease cystic fibrosis (CF) frequently leads to chronic lung infections by bacteria and fungi. We identified three individuals with CF with persistent lung infections dominated by ( ) . Whole genome sequencing analysis of multiple isolates from each infection found evidence for selection for mutants in the gene in all three distinct lung-associated populations.
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