Studying the Effect of Amino Acid Substitutions in the M2 Ion Channel of the Influenza Virus on the Antiviral Activity of the Aminoadamantane Derivative and .

The aminoadamantane derivative of L-histidyl-1-adamantayl ethylamine hydrochloride (HCl*H-His-Rim) has showed a high inhibition level against influenza A virus strains . The aim of this work is to search and establish evidence of the direct effect of the drug on influenza A virus proton channel M2. The compound HCl*H-His-Rim was obtained by classical peptide synthesis methods.