Publications by authors named "Marina Parezanovic"
Article Synopsis
- Phenylketonuria (PKU) is a genetic disorder that leads to high levels of phenylalanine, causing cognitive issues if untreated, but the exact brain effects of this condition are still unclear.
- This study used a new model of NT2-derived neurons treated with varying concentrations of phenylalanine to investigate gene expression changes linked to PKU-related brain impairment.
- The research found that specific genes were altered in response to phenylalanine, affecting neuronal processes like dendrite and axon development, ultimately highlighting the neurotoxic effects of high phenylalanine levels.
Systemic sclerosis (SSc) is a complex autoimmune inflammatory disorder with multiple organ involvement. Skin changes present the hallmark of SSc and coincide with poor prognosis. Interstitial lung diseases (ILD) are the most widely reported complications in SSc patients and the primary cause of death.
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