Current Molecular Profile of Gastrointestinal Stromal Tumors and Systemic Therapeutic Implications.

Gastrointestinal stromal tumors (GISTs) are malignant mesenchymal tumors arising from the intestinal pacemaker cells of Cajal. They compose a heterogenous group of tumors due to a variety of molecular alterations. The most common gain-of-function mutations in GISTs are either in the (60-70%) or platelet-derived growth factor receptor alpha () genes (10-15%), which are mutually exclusive.

Porous antibody-containing protein microparticles as novel carriers for ELISA.

A new strategy for ELISA-based detection in small volumes based on porous antibody-containing protein microparticles was developed and employed for the determination of human immunoglobulin G demonstrating both increase in sensitivity and decrease in antibody consumption by ten times compared to a conventional planar ELISA.

Laryngeal paracoccidioidomycosis presenting as solitary true vocal fold disease.

Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by or . It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement.