Publications by authors named "Marina Martjuga"
Article Synopsis
- Carbapenems are essential antibiotics but are losing effectiveness due to metallo-β-lactamases (MBLs), which are enzymes that break them down.
- Researchers discovered indole-2-carboxylates (InCs) as new inhibitors that can effectively target MBLs, maintaining activity against all major clinically relevant classes of these enzymes.
- In laboratory tests, InCs not only restored the effectiveness of carbapenems against drug-resistant Gram-negative bacteria but also demonstrated a good safety profile and strong efficacy when combined with the antibiotic meropenem in animal models of infection.
Chiral, nonracemic o-aminobenzylamines were prepared in a highly diastereoselective reduction of atropisomeric N-tert-butanesulfinylketimines. The ortho-substituent ensures the distinct reactivity of atropisomers 4d-f. The free energy of activation for atropisomerization of sulfinylimines 4d-f in THF-d(8) was determined by NMR methods to range from 70.
View Article and Find Full Text PDFChiral, nonracemic 1,3-diamines were prepared in a highly diastereoselective reduction of diaryl N-tert-butanesulfinylketimines. Correlation between facial selectivity of the reduction and E or Z geometry of the starting ketimines suggests involvement of a cyclic transition state for the reduction. The ortho-substituent controls the geometry of N-tert-butanesulfinylketimines in the solid state and provides additional stabilization of the cyclic transition state.
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