Can β-blockers influence regular daily physical activity?

Background: In hypertension, β-blockers have a high rate of nonadherence to treatment likely because of fatigue.

Methods: We evaluate daily physical activity and maximal exercise performance in 56 patients with hypertension (grades I-II), with and without β-blockers (bisoprolol 10 mg or atenolol 100 mg) added to standard treatment; 48 patients completed the study. Study tests were performed after 8 weeks of antihypertensive therapy without β blockers and after the following 8 weeks with β-blockers.