Publications by authors named "Marina Loid"
Article Synopsis
- The study looks at how the endometrium (the inner lining of the uterus) changes as women get older and whether these changes affect their ability to have babies.
- It was found that older women (over 45) have different endometrial cells and gene activity compared to younger women, which could make it harder for embryos to implant.
- The research included 44 women undergoing hormone treatment and examined biopsies to see how ready their endometrium was for pregnancy at different ages.
Article Synopsis
- Modern lifestyles are causing women to have babies later, which can lead to problems with getting pregnant as they age.
- Older age can affect the quality of eggs and the lining of the uterus (endometrium), which are important for pregnancy.
- There's not a lot of research on how the aging uterus affects getting pregnant, and this review aims to gather information to help improve understanding and treatment options.
Hyperandrogenic women with PCOS show disrupted decidualization (DE) and placentation. Dihydrotestosterone (DHT) is reported to enhance DE in non-PCOS endometrial stromal cells (eSC); however, this has not been assessed in PCOS cells (eSC). Therefore, we studied the transcriptome profile of non-decidualized (non-DE) and DE eSCs from women with PCOS and Ctrl in response to short-term estradiol (E2) and/or progesterone (P4) exposure with/without (±) DHT.
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