Publications by authors named "Marina L Egorova"
Article Synopsis
- A(H5Nx) avian influenza viruses are widespread and evolving, with a notable emergence of highly pathogenic A(H5N1) clade 2.3.4.4b reassortant viruses since 2020.
- Some of these viruses, particularly those isolated from mammals, carry a mutation (E627K) in the PB2 protein that enables adaptation to mammalian cells.
- Recent findings from Russia reveal a highly pathogenic A(H5N1) virus with the E627K mutation that shows increased virulence in mice and limited airborne transmission in ferrets, underscoring the need for ongoing surveillance to mitigate pandemic risks.
