Dietary selenium affects host selenoproteome expression by influencing the gut microbiota.

Colonization of the gastrointestinal tract and composition of the microbiota may be influenced by components of the diet, including trace elements. To understand how selenium regulates the intestinal microflora, we used high-throughput sequencing to examine the composition of gut microbiota of mice maintained on selenium-deficient, selenium-sufficient, and selenium-enriched diets. The microbiota diversity increased as a result of selenium in the diet.

Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.

Mutations of the photoreceptor retinol dehydrogenase 12 (RDH12) gene cause the early onset retinal dystrophy Leber congenital amaurosis (LCA) by mechanisms not completely resolved. Determining the physiological role of RDH12 in photoreceptors is the focus of this study. Previous studies showed that RDH12, and the closely related retinol dehydrogenase RDH11, can enzymatically reduce toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE), in vitro.

An effective numerical method for solving viscous-inviscid interaction problems.

This paper presents a new numerical method to solve the equations of the asymptotic theory of separated flows. A number of measures was taken to ensure fast convergence of the iteration procedure, which is employed to treat the nonlinear terms in the governing equations. Firstly, we selected carefully the set of variables for which the nonlinear finite difference equations were formulated.