Publications by authors named "Marina I Sekacheva"
Article Synopsis
- Anti-cancer treatments can lead to serious heart issues, which are a leading cause of death in cancer survivors, highlighting the need for ongoing heart monitoring during and after treatment.
- A study involving 162 cancer patients showed that remote single-lead ECG monitoring effectively detected early signs of cardiotoxicity, with significant occurrences of QTc prolongation and new atrial fibrillation after chemotherapy.
- Early identification of heart problems from cancer treatments can significantly improve patient safety, and using portable ECG devices is a practical and cost-effective way to monitor these risks.
Lung cancer is currently the second leading cause of cancer death worldwide. In recent years, checkpoint inhibitor immunotherapy (ICI) has emerged as a new treatment. A better understanding of the tumor microenvironment (TMJ) or the immune system surrounding the tumor is needed.
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- Research indicates that growth factors play a significant role in lung cancer angiogenesis, which helps tumors grow and spread by affecting the immune response.
- New treatment strategies focus on developing anti-angiogenic compounds that block the activity of these growth factors, particularly EGF and VEGF, to hinder lung cancer progression.
- While the initial results of these therapies are promising, there is a heightened risk of toxicity, necessitating personalized follow-up care for patients undergoing treatment.
Article Synopsis
- Normal tissues are crucial for studying gene expression related to diseases, but healthy controls are often obtained only post-mortem, leading researchers to use "normal" tissues next to tumors as controls.
- A study compared gene expression profiles in tumor-adjacent tissues to those from autopsy-derived healthy tissues, discovering significant differences linked to immune activation, cell signaling pathways, and structural changes.
- Using a macaque model, researchers identified RNA degradation in lung samples that affected gene expression results, emphasizing the need to consider sample quality and handling in research protocols.
The analysis of molecular mechanisms of disease progression challenges the development of bioinformatics tools and omics data integration [...
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- DNA repair mechanisms are crucial for maintaining genome integrity and limiting tumor progression, but they can also help tumors survive radiation and chemotherapy treatments.
- Research analyzed 38 DNA repair pathways across nine cancer types using RNAseq data from various databases, revealing a consistent downregulation of the G2/M checkpoint pathway and low p53 pathway activity in tumors.
- The study identified that despite most DNA repair pathways being upregulated, key genes associated with the G2/M checkpoint and p53 pathways were significantly disrupted, highlighting their unique roles in cancer development.
Article Synopsis
- - OncoboxPD is an extensive database of human molecular pathways, featuring over 51,000 pathways that map out protein-protein interactions and metabolic reactions, totaling over 361,000 interactions among 64,000 molecules.
- - It categorizes pathways by biological processes and uses algorithms to annotate pathway nodes, allowing users to determine pathway activation levels based on specific RNA/protein expression profiles.
- - Users can visualize pathways as static or dynamic graphs, highlight differentially expressed nodes, and generate summary graphs that display the most significant upregulated and downregulated pathways for their comparisons.
Article Synopsis
- The study reviews the link between mercury (Hg) exposure and cancer risk through various epidemiological and experimental studies over the last 20 years.
- While some studies show a strong connection between Hg exposure and increased cancer risk, others did not find any significant association.
- Experimental findings suggest that both high and low doses of Hg can lead to cellular damage and changes in signaling pathways that may promote cancer, alongside potential epigenetic effects that contribute to its carcinogenic properties.
Article Synopsis
- The study analyzes serum and hair levels of essential metals and metalloids in 310 women (ages 20-80) to identify patterns in those with benign breast disease, breast cancer, and healthy controls.
- Significant differences in metal levels were found, with breast cancer patients showing higher hair chromium (Cr) and vanadium (V), but lower copper (Cu) and manganese (Mn) compared to the other groups.
- The findings suggest that breast cancer development may relate to reduced systemic levels of Mn and zinc (Zn) alongside increased copper concentrations, while fibrocystic disease was associated with lower selenium (Se) levels.
Article Synopsis
- * Advances in cancer research help identify key molecular targets and improve therapies through better understanding of cancer biology, signaling pathways, and tumor-immune cell interactions.
- * The use of 3D multicellular cancer spheroids as models for drug screening and personalized therapy shows promise in enhancing NSCLC treatment effectiveness and tailoring strategies for individual patients.
Article Synopsis
- Inter-patient molecular heterogeneity in tumors is influencing the development and personalization of anticancer drugs, leading to varied treatment options.
- A comprehensive analysis of 4,890 tumors revealed that the molecular targets of accepted cancer drugs do not align with tumor heterogeneities across thirteen major cancer types.
- The study found that clinical recommendations for drug use correlate more with gene expression patterns than mutation patterns, highlighting opportunities for improving targeted therapies, especially in certain cancer types like kidney and ovarian cancers.
Article Synopsis
- The study focused on classifying breast cancer (BC) methylotypes using advanced DNA sequencing techniques to analyze DNA methylation in 110 BC samples and 6 normal breast samples.
- Researchers found six distinct BC methylotypes through unsupervised analysis and identified specific genes that show different methylation patterns across these types.
- The results suggest that BC can be categorized into highly and moderately methylated subtypes, indicating potential new strategies for personalized treatment based on these epigenomic features.
Article Synopsis
- Ovarian cancer ranks as the fifth most common cause of cancer deaths among women and is the deadliest type of gynecological cancer.
- The report discusses a unique case of a 26-year-old woman with a recurrent granulosa cell tumor (GCT) in her right ovary that continued to progress despite various treatments.
- Utilizing a new bioinformatics tool called Oncobox, doctors identified actionable drug options that resulted in a partial response and eventually stabilized her condition over the long term.
Article Synopsis
- - Cholangiocarcinoma is a severe cancer with a low survival rate, often diagnosed too late for surgical treatment and usually managed with chemotherapy that only offers about a 12-month median survival.
- - A case study involving a 72-year-old man with aggressive metastatic cholangiocarcinoma showcases the use of personalized treatment through tyrosine kinase inhibitors (TKIs), starting with sorafenib, which stabilized his condition and improved quality of life for nearly 6 months before switching to Pazopanib.
- - The study highlights the potential benefits of tailoring TKI therapy based on genetic testing of the tumor, suggesting that personalized treatments can extend survival and enhance the patient's quality of life beyond typical chemotherapy outcomes.