Selective C-N Bond Cleavage in Unstrained Pyrrolidines Enabled by Lewis Acid and Photoredox Catalysis.

Cleavage of inert C-N bonds in unstrained azacycles such as pyrrolidine remains a formidable challenge in synthetic chemistry. To address this, we introduce an effective strategy for the reductive cleavage of the C-N bond in -benzoyl pyrrolidine, leveraging a combination of Lewis acid and photoredox catalysis. This method involves single-electron transfer to the amide, followed by site-selective cleavage at the C2-N bond.

Heparin is a promising agent for the treatment of endometriosis-associated fibrosis.

Objective: To assess the use of heparin for the medical treatment of endometriosis-associated fibrosis.

Design: The effects of heparin on the endometriotic stromal cells (ECSCs)-mediated contractility were investigated.

Setting: Research laboratory at a medical school.