Perceptions of research integrity and open science practices: a survey of Brazilian dental researchers.

The objective of this study was to evaluate Brazilian dental researchers' perceptions of research integrity and open science practices, as well as their perceptions of the way researchers are evaluated for promotion, hiring, and receiving grants. In a self-administered online survey, the respondents were presented with 3 questions on researcher evaluation in Brazil. Additionally, for 25 academic activities or characteristics, researchers rated their perceived importance for a) career advancement, b) science advancement, c) personal satisfaction, and d) social impact.

Impact of Radiation on Invasion and Migration of Glioma In Vitro and In Vivo.

Glioblastoma (GBM) constitutes the most common primary brain tumor and it remains incurable despite therapeutic advances. The high infiltration/invasion potential of GBM cells is considered to be one of the reasons for the inevitable recurrence of the disease. Radiotherapy (RT) is part of the standard care for patients with GBM, and its benefits on overall survival are extensively reported.

Critical Feminist Epidemiology in Action: Reflections from a Multidisciplinary Partnership Between Mujeres Unidas y Activas and Academic Researchers.

Critical feminist research addresses social inequities, encourages equitable partnerships between researchers and participants, and acknowledges that research can be inherently political. Building upon critical feminist research practices, community-based participatory research, and social and structural epidemiology, we propose the approach of critical feminist epidemiology. A critical feminist epidemiology approach can study community and population health inequities with an eye towards identifying interventions that reduce inequities, through research processes that center the lived experiences of people from minoritized genders.

Persistent gender disparity in leading dental publications across 4 decades: an observational study.

Objectives: This observational study assessed the differences in the gender of the first and last authors in the most-cited dental articles over the last 4 decades.

Study Design And Setting: Articles were obtained through an electronic search of the most-cited articles in dentistry by decade (total n = 400 articles). The 100 most-cited studies in each decade (1980-1989, 1990-1999, 2000-2009, and 2010-2019), with any study design, with results in dentistry were eligible.

The impact of gender on citation rates: An observational study on the most cited dental articles.

Objective: This cross-sectional study aims to determine whether the gender of the authors plays a role in the position of authorship within the 100 most cited articles in dentistry.

Methods: An electronic search was performed in October 2022 in the SCOPUS database, considering filters by 'subject area' [dentistry], 'document type' [article], and 'source type' [journal]. The search was performed without restriction on the study design, publication yearor language.

Impact of COVID-19 on gender gap in dental publications: a retrospective cohort with three Brazilian journals.

This was a retrospective cohort study to investigate the impact of COVID-19 pandemic on the gender gap in articles submitted to three international dental journals based in Brazil. All submissions performed to Brazilian Dental Journal, Brazilian Oral Research, and Journal of Applied Oral Science before (2019) and during the pandemic (2020) were assessed. Gender of the first, last, and corresponding authors were collected.

Delivery of Molecules Using Nanoscale Systems for Cancer Treatment and/or Diagnosis.

Since clinical approval of the first liposomal formulation encapsulating a chemotherapeutic agent, nanoscale delivery systems have been a rapidly developing science [...

Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy.

Cancer is responsible for a significant proportion of death all over the world. Therefore, strategies to improve its treatment are highly desired. The use of nanocarriers to deliver anticancer treatments has been extensively investigated and improved since the approval of the first liposomal formulation for cancer treatment in 1995.

Open science failed to penetrate academic hiring practices: a cross-sectional study.

Background And Objective: To evaluate the current hiring practices of academic institutions around the world, with regard to the mention of advertisements for Open Science (OS) in research based, faculty, and postdoctoral positions.

Study Design: Cross-sectional study, using 189 global institutions from the Center for Science and Technology Leiden ranking of world universities of 2017, including the U15 Group (Canadian Research-Intensive Universities), and five self-selected supplementary institutions.

Methods: The main outcome measure for our study is the level of OS in job advertisements, assessed using the Modified Open Science Modular Scheme.

The impact of gender on researchers' assessment: A randomized controlled trial.

Objectives: This randomized controlled trial aimed to test whether women or men would be preferred with identical curriculum vitae (CV); and the impact of the career stage in the evaluators' choice.

Study Design And Setting: A simulated post-doctoral process was carried forward to be assessed for judgment. Level 1 and 2 Brazilian fellow researchers in the field of Dentistry were invited to act as external reviewers in a post-doctoral process and were randomly assigned to receive a CV from a woman or a man.

Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment.

Since more than 40 years liposomes have being extensively studied for their potential as carriers of anticancer drugs. The basic principle behind their use for cancer treatment consists on the idea that they can take advantage of the leaky vasculature and poor lymphatic drainage present at the tumor tissue, passively accumulating in this region. Aiming to further improve their efficacy, different strategies have been employed such as PEGlation, which enables longer circulation times, or the attachment of ligands to liposomal surface for active targeting of cancer cells.

The impact of gender on scientific writing: An observational study of grant proposals.

Objectives: This study aimed to determine whether there are differences in the language used in grant applications submitted to a Southern Brazil Research Support Foundation (FAPERGS) according to the gender, career stage, and the number of publications of applicants.

Study Design And Setting: This observational study also evaluated the relationship between gender, career stage, curriculum, and writing characteristics. Summaries of all research proposals in the biomedical field of FAPERGS during the years of 2013 and 2014 were evaluated according to six language patterns (Positive emotions, Negative emotions, Analytic thinking, Clout, Authenticity, and Emotional tone) defined by the LIWC software.

Transparency in clinical trials: Adding value to paediatric dental research.

Background: Even though considered as studies with high methodological power, many RCTs in paediatric dentistry do not have essential quality items in their design, development, and report, making results' reliability questionable, replication challenging to conduct, wasting time, money, and efforts, and even exposing the participants to research for no benefit.

Aim: We addressed the main topics related to transparency in clinical research, with an emphasis in paediatric dentistry.

Design: We searched for all controlled clinical trials published from January 2019 up to July 2020 in the three paediatric dentistry journals with high journal Impact Factor, indexed on Medline.

Combined paclitaxel-doxorubicin liposomal results in positive prognosis with infiltrating lymphocytes in lung metastasis.

To investigate the effect of liposomes containing the classical cytotoxic drugs paclitaxel and doxorubicin (Lipo-Pacli/Dox), against a metastatic breast cancer model. We also investigated if Lipo-Pacli/Dox was capable of reverting the tolerogenic environment of metastatic lesions. Immunogenic cell death induction by the Pacli/Dox combination was assessed .

Development of Long-Circulating and Fusogenic Liposomes Co-encapsulating Paclitaxel and Doxorubicin in Synergistic Ratio for the Treatment of Breast Cancer.

Background: The co-encapsulation of paclitaxel (PTX) and doxorubicin (DXR) in liposomes has the potential to offer pharmacokinetic and pharmacodynamic advantages, providing delivery of both drugs to the tumor at the ratio required for synergism.

Objective: To prepare and characterize long-circulating and fusogenic liposomes co-encapsulating PTX and DXR in the 1:10 molar ratio (LCFL-PTX/DXR).

Methods: LCFL-PTX/DXR was prepared by the lipid film formation method.

Short and Long-Term Effects of the Exposure of Breast Cancer Cell Lines to Different Ratios of Free or Co-Encapsulated Liposomal Paclitaxel and Doxorubicin.

Background: Associating paclitaxel (PTX) to doxorubicin (DXR) is one of the main chemotherapy strategies for breast cancer (BC) management. Protocols currently available consist in administering both drugs on their maximum tolerated dose, not taking into account the possible differences in efficacy due to their combination ratio. In the present study, the short and long-term cytotoxic effects as well as migratory effects of PTX, DXR, and its combinations at 10:1; 1:1 and 1:10 PTX:DXR molar ratios either free or co-encapsulated in liposomes were evaluated against three human BC cell lines (MDA-MB-231, MCF-7, and SKBR-3).

Factors affecting the color stability and staining of esthetic restorations.

This study aimed to assess the color stability of two composite resins, unprotected or protected with a hydrosoluble gel (oxygen inhibitor) during final polymerization, when subjected to different staining solutions and daily tooth brushing simulation. Nanohybrid composite (IPS Empress Direct) or nanofilled composite (Filtek Z350) were used to produce round samples that were either unprotected or protected with a hydrosoluble gel before the final cycle of polymerization. For 5 days, the samples were immersed for 1 h/day in four different staining solutions: distilled water (control), coffee, soft drink, and red wine.

Investigation of the antitumor activity and toxicity of long-circulating and fusogenic liposomes co-encapsulating paclitaxel and doxorubicin in a murine breast cancer animal model.

To associate paclitaxel (PTX) with doxorubicin (DXR) is one of the main chemotherapy strategies for breast cancer (BC) management. Despite the high response rates for this combination, it presents a cardiotoxic synergism, attributed to pharmacokinetic interactions between PTX and both DXR and its metabolite, doxorubicinol. One of the main strategies to minimize the cardiotoxicity of the combination is to extend the interval of time between DXR and PTX administration.

Liposomes Co- encapsulating Anticancer Drugs in Synergistic Ratios as an Approach to Promote Increased Efficacy and Greater Safety.

The era of chemotherapy began in the 1940s, but it was in the 1960s that it was seen as really promising when the first patients with childhood acute lymphoblastic leukemia were cured with combination chemotherapy. Today, it is known that due to resistance to single agents, combination therapy is essential for tumor eradication and cure. In the last decade, studies have shown that anticancer drug combinations can act synergistically or antagonistically against tumor cells , depending on the ratios of the individual drugs forming the combination.

Ratiometric drug delivery using non-liposomal nanocarriers as an approach to increase efficacy and safety of combination chemotherapy.

The observation that different drug ratios of the same drug combination can lead to synergistic or antagonistic effects when tested against the same cancer cell line in vitro gave rise to a new trend, the ratiometric delivery. This strategy consists of co-encapsulating a specific synergistic ratio of a drug combination into a nanocarrier so that synergism observed in vitro will be faithfully translated to in vivo, optimizing combination therapy. In this review we focus on how to quantify synergism in vitro, followed by how this affected the evolution of nanocarriers culminating in the ratiometric delivery, and finally we summarize the results of the non-liposomal formulations that were built upon this concept.

Reduced Plasma Levels of sCD14 and I-FABP in HIV-infected Patients with Mesalazine-treated Ulcerative Colitis.

Background: Microbial translocation (MT) is a shared feature of HIV infection and inflammatory bowel disease (IBD).

Aims: This study was conducted to assess the impact of IBD (and particularly ulcerative colitis, UC) on plasma markers of MT and immune activation in HIV+ subjects.

Methods: A cross-sectional study was conducted in 3 groups of patients: HIV+/UC+(group HIV/UC); HIV+/UC- (group HIV); HIV-/UC+(group UC).

pH-sensitive liposomes for drug delivery in cancer treatment.

In recent years, liposomes have been employed with growing success as pharmaceutical carriers for antineoplastic drugs. One specific strategy used to enhance in vivo liposome-mediated drug delivery is the improvement of intracytoplasmic delivery. In this context, pH-sensitive liposomes (pHSLip) have been designed to explore the endosomal acidification process, which may lead to a destabilization of the liposomes, followed by a release of their contents into the cell cytoplasm.

Crystal structure, antibacterial and cytotoxic activities of a new complex of bismuth(III) with sulfapyridine.

A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl₃(C₁₁H₁₁N₃O₂S)₃].

Application of CZE Method in Routine Analysis for Determination of B-Complex Vitamins in Pharmaceutical and Veterinary Preparations.

A competitive CZE method for quality control analysis of multivitamin preparations and veterinary products containing B-group vitamins was developed. Vitamins of interest are thiamine hydrochloride (B(1)), thiamine monophosphate chloride (B(1a)), riboflavine (B(2)), riboflavine-5'monophosphate (B(2a)), nicotinamide (B(3)), d-pantothenic acid calcium salt (B(5)), pyridoxine hydrochloride (B(6)), folic acid (B(9)), and 4-aminobenzoic acid (B(10)). These analytes were separated optimizing the experimental conditions in 20 mM tetraborate buffer pH = 9.