Publications by authors named "Marina Ferreira Candido"
Estrogen deficiency, long-term immobilization, and/or aging are commonly related to bone mass loss, thus increasing the risk of fractures. One option for bone replacement in injuries caused by either traumas or pathologies is the use of orthopedic cement based on polymethylmethacrylate (PMMA). Nevertheless, its reduced bioactivity may induce long-term detachment from the host tissue, resulting in the failure of the implant.
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- Childhood cancer, though rare, leads to significant mortality, with a child dying from cancer every 3 minutes globally, highlighting the need for better treatment options.
- The study focuses on analyzing kinase functionality in pediatric solid tumors, exploring their expression patterns and correlation with clinical outcomes, as well as investigating the effectiveness of kinase inhibitors.
- A review of small molecules targeting kinases and their potential clinical applications is provided, while addressing challenges such as lack of specific compounds for childhood cancers and issues with resistance.
Head and neck squamous cell carcinoma remains challenging to treat with no improvement in survival rates over the past 50 years. Thus, there is an urgent need to discover more reliable therapeutic targets and biomarkers for HNSCC. Matriptase, a type-II transmembrane serine protease, induces malignant transformation in epithelial stem cells through proteolytic activation of pro-HGF and PAR-2, triggering PI3K-AKT-mTOR and NFKB signaling.
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- Despite understanding the biology of pediatric CNS malignancies, prognosis for patients remains poor.
- This review focuses on the NF-kB signaling pathway, which is often disrupted in cancer and impacts cell growth and treatment resistance.
- It discusses various NF-kB inhibitors and their potential in improving treatment outcomes for common pediatric CNS tumors like gliomas, medulloblastomas, and ependymomas.