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Publications by authors named "Marina Dal'Bo Pelegrini"

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Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents.
Marina Dal'Bó Pelegrini Juliana Biar Pereira Solange Dos Santos Costa Myriam Janeth Salazar Terreros Adriana Degrossoli

Asian Pac J Trop Med

July 2016

Objective: To evaluate whether hypoxia inducible factor (HIF-1α) targeting pharmacological drugs, echinomycin, resveratrol and CdCl2 which inhibit HIF-1α stimulation, and mimosine, which enhances the stability of HIF-1α present antileishmanial properties.

Methods: The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous leishmaniosis.

Results: Resveratrol and CdCl2 reduced the parasite load [IC50, (27.

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