Publications by authors named "Marina C Leroy"
Article Synopsis
- Human myoblast differentiation requires a hyperpolarization of the resting potential, driven by the activation of Kir2.1 potassium channels, which are regulated by tyrosine phosphorylation.
- Epidermal Growth Factor Receptor (EGFR) is identified as a critical regulator of this differentiation, with its activity decreasing during the early stages necessary for normal differentiation to occur.
- Silencing EGFR in proliferating myoblasts can initiate differentiation by increasing Kir2.1 channel activity and enhancing calcium entry, leading to the expression of muscle-specific proteins, although simply blocking the cell cycle does not initiate differentiation on its own.
