Publications by authors named "Marina Bruch-Oms"
Article Synopsis
- * Deleting Snail1 in CAFs reduced their ability to polarize bone-marrow-derived macrophages (BMDMΦs) towards an immunosuppressive phenotype, compared to those exposed to active CAFs, which inhibited macrophage cytotoxicity.
- * Active CAFs also promoted gene expressions related to immunosuppression in macrophages and the activation of regulatory T cells (T-regs), suggesting that CAFs in the tumor microenvironment hinder anti-tumor immunity. *
Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAFs and other mesenchymal cells rely much more on glutamine than epithelial tumor cells; consequently, they are more sensitive to inhibition of glutaminase. Glutamine dependence drove CAF migration toward this amino acid when cultured in low glutamine conditions.
View Article and Find Full Text PDFArticle Synopsis
- Cancer cells make tiny bubbles called extracellular vesicles (EVs) that carry special molecules like RNA and proteins, which help them grow and resist treatment.
- These EVs can connect to other cancer cells through a special "bridge" made by a protein called CCL18 and a receptor on the cell called CCR8.
- By using a specific blocker for CCR8, scientists found a way to stop the helpful effects of EVs in brain tumors like glioblastoma, which could lead to new treatments.