Barriers and facilitators to application of treat-to-target management in psoriatic arthritis and axial spondyloarthritis in practice: A systematic literature review.

Objective: To review the evidence on barriers and facilitators to application of treat-to-target (T2T) in axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) in daily practice.

Methods: A systematic search was conducted in MEDLINE/Embase up to December 2023, focusing on axSpA/PsA. Any type of quantitative/qualitative original research was eligible for inclusion if barriers or facilitators to application of T2T were explored.

Factors associated with treatment intensification in patients with axial spondyloarthritis and high disease activity in clinical practice.

Objective: To investigate which factors are associated with treatment intensification (TI) in axial spondylarthritis (axSpA) patients with high disease activity (HDA).

Methods: Patients with axSpA and HDA (Ankylosing Spondylitis Disease Activity Score [ASDAS]≥2.1) from the Dutch SpA-Net registry were included.

Go or no-go for treat-to-target in axial spondyloarthritis?

Purpose Of Review: For almost a decade, treat-to-target (T2T) has been advocated as a management strategy for axial spondyloarthritis (axSpA), despite a lack of trial evidence. Recently, the first and only published T2T trial in axSpA did not meet its primary endpoint. The purpose of this review is to discuss whether we should continue with a T2T approach in axSpA and to describe some experiences with T2T in clinical practice.

Performance of 3 Composite Measures for Disease Activity in Peripheral Spondyloarthritis.

Objective: To investigate concurrent validity and discrimination of the Disease Activity Index for Psoriatic Arthritis (DAPSA) score, Psoriatic Arthritis Disease Activity Score (PASDAS), and Ankylosing Spondylitis Disease Activity Score (ASDAS) in peripheral spondyloarthritis (pSpA) in clinical practice.

Methods: Data from a Dutch registry for SpA (SpA-Net) were used. Predefined hypotheses on concurrent validity of the composite measures with 15 other outcome measures of disease activity, physical function, and health-related quality of life were tested.

Posttraining transcranial magnetic stimulation of striate cortex disrupts consolidation early in visual skill learning.

Practice-induced improvements in skilled performance reflect "offline " consolidation processes extending beyond daily training sessions. According to visual learning theories, an early, fast learning phase driven by high-level areas is followed by a late, asymptotic learning phase driven by low-level, retinotopic areas when higher resolution is required. Thus, low-level areas would not contribute to learning and offline consolidation until late learning.

Time-limited consolidation and task interference: no direct link.

Perceptual skills improve with daily practice (Fahle and Poggio, 2002; Fine and Jacobs, 2002). Practice induces plasticity in task-relevant brain regions during an "offline" consolidation period thought to last several hours, during which initially fragile memory traces become stable (Karni, 1996; Dudai, 2004). Impaired retention of a task if followed by training in another task is considered evidence for the instability of memory traces during consolidation (Dudai, 2004).

A detailed analysis of rats' spatial memory in a probe trial of a Morris task.

In the present study, we evaluated the search behavior of rats during a probe trial of a Morris water escape task. More specifically, the spatial memory during different stages of a 2 min probe trial in different zones was examined. After rats were trained for 4 days with four trials per day, their spatial memory was tested in a first probe trial.