Publications by authors named "Marilyne Giroux-Dansereau"
Article Synopsis
- Endocytic trafficking, particularly involving sorting nexins (SNXs) like SNX1 and SNX2, plays a vital role in regulating receptor signaling related to diseases, especially in colorectal cancer (CRC).
- The study found that knocking out SNX1 and SNX2 genes in human CRC cells delays the entry of the MET receptor into early endosomes, resulting in increased phosphorylation of MET and AKT, which are crucial for signaling, but does not impact ERK1/2 phosphorylation.
- Moreover, while the absence of SNX1 and SNX2 did not alter HGF-induced cell behaviors like proliferation and migration, it led to higher resistance to TRAIL-induced apoptosis, highlighting the important connection between intracellular trafficking and
