Radiological Assessment and Outcome of Local Disease Progression after Neoadjuvant Chemotherapy in Children and Adolescents with Localized Osteosarcoma.

Objective: We examined the interobserver reliability of local progressive disease (L-PD) determination using two major radiological response evaluation criteria systems (Response evaluation Criteria in Solid Tumors (RECIST) and the European and American Osteosarcoma Study (EURAMOS)) in patients diagnosed with localized osteosarcoma (OS). Additionally, we describe the outcomes of patients determined to experience L-PD.

Materials And Methods: Forty-seven patients diagnosed with localized OS between 2000 and 2012 at our institution were identified.

False-positive In-111 DTPA octreotide scintigraphy in bilateral tibial insufficiency fracture.

We present a case of bilateral tibial insufficiency fracture in which indium (In)-111 diethylenetriamine pentaacetic acid (DTPA) octreotide scan showed increased activity in the region of the fracture. The scan was performed in a 5-year-old girl with severe refractory hypertension and elevated plasma metanephrines for evaluation of possible neuroendocrine tumor. Octreotide scan is usually positive in neuroendocrine and some other tumors but also shows positive results in a number of other conditions.

Imaging of pediatric musculoskeletal infection.

Musculoskeletal infections in children present a diagnostic challenge because they are difficult to recognize in the early stages of the disease and can be confused with other pathology such as tumors or trauma. The severity of disease may be associated with the primary tissue of involvement with bone greater than joint, greater than muscle, greater than soft tissue. The incidence of musculoskeletal infection is higher in infants and young children, and risk factors include premature birth, umbilical catheterization, urinary tract infection, immunodeficiency, and other preexisting disease.