Effect of preoperative exercise on postoperative mobility in obese total joint replacement patients.

There has been a significant increase in obesity in the United States over the past 20 years. Reports in the literature identify the association of obesity-related osteoarthritis and the likelihood of future total hip arthroplasty (THA) and total knee arthroplasty (TKA) in this patient population. However, little is known about the effect of preoperative exercise on immediate postoperative mobility and discharge disposition in obese total joint replacement patients.

Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.

Pseudomonas aeruginosa uses quorum sensing, an interbacterial communication system, to regulate gene expression. The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a central role in quorum sensing. Since 3OC12-HSL can be degraded by paraoxonase (PON) family members, we hypothesized that PONs regulate P.

What did they know? And when did they know it? Progress in helping clinicians reach decisions.

In the past three decades, knowledge professionals have made remarkable strides toward achieving clinicians' decision-support dream of immediately available short answers. Medical evidence, what is truly known about health care effects and ready to be applied in patient care, can now much more easily be identified. Today's information delivery tools enable clinicians to seek answers to many more of their questions and to find the answers when patient encounters and teachable moments are occurring.