Publications by authors named "Marilu Gorno Tempini"
Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
Alzheimers Dement (Amst)
September 2023
Article Synopsis
- * A study applied a polygenic hazard score to early-onset AD patients and found that their scores were similar to those of late-onset patients, suggesting that genetic factors associated with late-onset AD do not explain early-onset cases.
- * The research indicates that early-onset AD has a distinct genetic makeup compared to late-onset AD, highlighting the need for further investigation into unique genetic factors related to early-onset AD.
Objective: The purpose of this study was to compare the diagnostic accuracy of antemortem C-Pittsburgh compound B (PIB) and F-fluorodeoxyglucose (FDG) positron emission tomography (PET) versus autopsy diagnosis in a heterogenous sample of patients.
Methods: One hundred one participants underwent PIB and FDG PET during life and neuropathological assessment. PET scans were visually interpreted by 3 raters blinded to clinical information.
Clinicians often use speech to characterize neurodegenerative disorders. Such characterizations require clinical judgment, which is subjective and can require extensive training. Quantitative Production Analysis (QPA) can be used to obtain objective quantifiable assessments of patient functioning.
View Article and Find Full Text PDFObjective: To compare the sensitivity of structural MRI and F-fludeoxyglucose PET (FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD).
Methods: Thirty patients with behavioral variant FTD (bvFTD), 7 with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), 16 with semantic variant primary progressive aphasia (svPPA), and 43 cognitively normal controls underwent 2-4 MRI and FDG-PET scans (total scans/visit = 270) as part of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study. Linear mixed-effects models were carried out voxel-wise and in regions of interest to identify areas showing decreased volume or metabolism over time in patients as compared to controls.
Among primary progressive aphasias (PPAs), logopenic variant PPA (lv-PPA) is usually related to Alzheimer's disease. Although it has been widely clinically and pathologically evaluated, the topography in LPA is still controversial. We report a patient presenting with a logopenic syndrome due to a strategic lesion located in the superior and middle temporal gyrus and compare our findings with those of a PiB-PET positive lv-PPA patient matched by age, gender, and education.
View Article and Find Full Text PDFIntroduction: Group comparisons demonstrate greater visuospatial and memory deficits and temporoparietal-predominant degeneration on neuroimaging in patients with corticobasal syndrome (CBS) found to have Alzheimer's disease (AD) pathology versus those with underlying frontotemporal lobar degeneration (FTLD). The value of these features in predicting underlying AD pathology in individual patients is unknown. The goal of this study is to evaluate the utility of modified clinical criteria and visual interpretations of magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) for predicting amyloid deposition (as a surrogate of Alzheimer's disease neuropathology) in patients presenting with CBS.
View Article and Find Full Text PDFAbstracts of the IX Congresso Sindem: Italian Association for the study of Dementia linked to the Italian Neurological Society (SIN), March 13-15, 2014, Florence, Italy.
J Alzheimers Dis
June 2015
Objective: To evaluate the effect of amyloid imaging on clinical decision making.
Methods: We conducted a retrospective analysis of 140 cognitively impaired patients (mean age 65.0 years, 46% primary β-amyloid (Aβ) diagnosis, mean Mini-Mental State Examination 22.