Publications by authors named "Mariliza Velho Rodrigues"
Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature.
Ester Cerdeira Sabino Lucas Augusto Moysés Franco Gabriela Venturini Mariliza Velho Rodrigues Emanuelle Marques
PLoS Negl Trop Dis
October 2022
Article Synopsis
- - Chronic Chagas Cardiomyopathy (CCC) develops years after parasitic infection and is a major cause of heart failure in Latin America, yet only a small percentage of infected individuals develop the disease.
- - A genome-wide association study (GWAS) identified a new susceptibility locus (rs34238187) linked to CCC in Brazilian populations, with significant associations to various immune-related traits.
- - The findings suggest that this genetic locus plays a role in modifying the immune response to the T. cruzi parasite, highlighting the need for further research into its functional character and impact on CCC risk.
NADPH oxidase p22phox subunit is responsible for the production of reactive oxygen species in the vascular tissue. The C242T polymorphism in the p22phox gene has been associated with diverse coronary artery disease phenotypes, but the findings about the protective or harmful effects of the T allele are still controversial. Our main aim was to assess the effect of p22phox C242T genotypes on arterial stiffness, a predictor of late morbidity and mortality, in individuals from the general population.
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