Publications by authors named "Marilisa Schiwek"
Objectives: Pulmonary perfusion abnormalities are prevalent in patients with chronic obstructive pulmonary disease (COPD), are potentially reversible, and may be associated with emphysema development. Therefore, we aimed to evaluate the clinical meaningfulness of perfusion defects in percent (QDP) using DCE-MRI.
Methods: We investigated a subset of baseline DCE-MRIs, paired inspiratory/expiratory CTs, and pulmonary function testing (PFT) of 83 subjects (age = 65.
Article Synopsis
- Childhood interstitial lung disease (chILD) includes over 200 rare lung disorders with no approved treatments and varying outcomes; this study investigates nintedanib, a drug that has shown promise in adults with similar diseases, in children aged 6-17 with fibrosing chILD.
- The trial is a multicenter, double-blind, randomized, placebo-controlled study where participants will take oral nintedanib or a placebo for 24 weeks, with dosing based on body weight and flexibility for dose adjustments if side effects arise.
- Primary endpoints focus on the drug's pharmacokinetics and side effects at week 24, while secondary endpoints assess changes in lung function, quality of life, oxygen levels, and walking