Publications by authors named "Marilis Dallarmi Miguel"

Article Synopsis
  • * Studies on Symplocos tetrandra using light and scanning electron microscopy revealed key anatomical features, such as calcium oxalate crystals and specialized stomata, useful for species identification.
  • * The presence of these metabolites and unique anatomical markers indicates potential for further pharmacological research and taxonomic classification of S. tetrandra.
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The order Sapindales is comprised of nine families and in Brazil it is represented by six, including Rutaceae Juss., which constitutes the largest group of this order. A variety of species of Zanthoxylum L.

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Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds. In this perspective, this literature review presents isolated molecules and extracts of natural products capable of inhibiting the activity of the nonstructural protein that acts as the RNA-dependent RNA polymerase.

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The genus exhibits a variety of pharmacological, antibacterial and antioxidant effects. The aim of the present study was to evaluate the antioxidant potential and antibacterial properties of the ethyl acetate fraction of leaves. Isolation and identification of the phenolic compounds from the fraction was also carried out.

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Introduction: Aedes aegypti is the main vector of dengue and yellow fever. Recently, the use of plant-sourced larvicides has gained momentum.

Methods: The hydroethanolic extracts and fractions ofOcotea nutansleaves and stems were bioassayed to determine the larvicidal efficacy of these samples.

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The growing interest in the discovery of new compounds from medicinal plants justifies the study of phytochemical components of these plants and their biological activities. The genus exhibits a variety of pharmacological, antimicrobial and antioxidant effects. The aim of the present study was to evaluate the antioxidant potential and antimicrobial properties of the ethyl acetate fraction of leaves.

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Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the genus is extensively researched for presenting such activities. This work aims to evaluate the antifungal, antibacterial, and antioxidant properties of extracts and fractions of stems of , also to characterize two phenolic compounds.

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Article Synopsis
  • Various factors like temperature, pH, and culture medium influence the growth of fungi and the production of important compounds.
  • Studies on the metabolites produced by specific fungi are limited, although they have potential for biotechnological use.
  • The highest growth of mycelial mass from a certain fungus occurred at 24°C using potato dextrose and malt extract media, and the disaccharide α-α-trehalose was newly identified in this genus through X-ray diffraction analysis.
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Several essential oils have allelochemicals with phytotoxic effects. species are producers of secondary metabolites with biological potential. In the present study, chemical composition of the essential oil extracted from aerial parts of Linnaeus was evaluated by gas chromatography and the phytotoxicity of the oil on seeds was evaluated for the first time.

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The aim of this work is to develop a W/O/W multiple emulsion with gallic acid in the internal aqueous phase (W). A quantification method for gallic acid using HPLC-UV was developed and validated. In the first step, a simple W/O emulsion was prepared with distilled water, polyglycerol polyricinoleate, sodium chloride, gallic acid and pH 5.

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This article enumerates the detailed anatomy of Cantinoa althaeifolia (Lamiaceae) illustrated with light and scanning electron microscopy images. The anatomical markers include the presence of branched nonglandular trichomes and capitate, peltate, and clavate types of glandular trichomes; prismatic crystals on the leaf and stem surfaces; and oil droplets in the leaf mesophyll. Histochemical tests and EDS analyses were performed in order to detect the composition of certain cells and their contents.

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Bixin is the main natural apocarotenoid extracted from the seeds of widely used as a cosmetic and textile colorant. Despite the description of several pharmacological properties of extracts, little has been studied regarding the pharmacological properties of bixin. Then we aimed to investigate the potential anti-inflammatory and antinociceptive effect of bixin in preclinical models of inflammation and acute pain.

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The Lauraceae family is predominantly found in Asia and in the rainforests of the Americas, and consists mostly of aromatic trees. Being an essential oil producer, this family is used in the food, pharmaceutical, and cosmetic industries. This work presents a systematic review of the chemical composition and bioactivity of the essential oils from the Lauraceae family.

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Article Synopsis
  • Diplodia pinea was tested for its ability to inhibit the growth of several fungi, including Armillaria sp. and Botrytis cinerea, using a method where two fungi strains are grown together.
  • The study found that D. pinea significantly inhibited the growth of all tested fungi, showing a range of 30.75% to 98.37% inhibition and a moderate antagonist activity index of 14.5.
  • Chemical analysis identified certain compounds in D. pinea, such as steroids and phenolic compounds, which likely contribute to its ability to compete for resources with other fungi.
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Article Synopsis
  • - Antimicrobial resistance is a serious global health issue, as common pathogens have become resistant to treatments, increasing the need for new antimicrobial agents from natural sources.
  • - The study focuses on the genus, which includes about 1000 species known for their medicinal properties, including antidiabetic and antibacterial effects, and aims to compile data on their phytochemical composition and antimicrobial activity.
  • - After analyzing 93 studies, results indicate that these species are rich in beneficial compounds like flavonoids and tannins, which contribute to their antimicrobial properties, although some species demonstrate significant cytotoxic effects.
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Background: Plants and their parts are a part of life in many Brazilian communities, as observed in the jackfruit. The jackfruit seeds are consumed, usually, as roasted, boiled, steamed, and are eaten as a snack.

Objective: The present study was carried out to identify the seeds toxicity and cytotoxic activity.

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  • This study explored the cytotoxic effects of Bacharis milleflora essential oil on Jurkat, Raji, and HL-60 cancer cells, examining how it affects cell death mechanisms.
  • Key volatile compounds identified in the oil include bicyclogermacrene, germacrene D, (E)-caryophyllene, and α-humulene, which contributed to a significant decrease in cell proliferation, especially in Raji cells.
  • The essential oil caused cell cycle arrest and fragmentation, inducing apoptosis and some necrosis, with a selectivity index of 3.97, showing its potential for therapeutic applications against certain tumors.
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The tea of aerial parts of Griseb. (Smilacaceae) has been ethnopharmacologically used in Southern Brazil due to its anti-inflammatory action. In this study, ethanolic and organic extracts from aerial parts of were phytochemically and pharmacologically characterized.

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Article Synopsis
  • Dugesia tigrina, a non-parasitic flatworm, has been used in pharmacological studies due to its high sensitivity to drugs affecting the nervous system.
  • A study was conducted to evaluate the effectiveness of four Alzheimer’s medications (donepezil, tacrine, galantamine, rivastigmine) on inhibiting the enzyme acetylcholinesterase by testing five drug concentrations.
  • Galantamine demonstrated the strongest inhibitory effect, significantly reducing convulsant activity and locomotion in the planarians, indicating its potential for further research using this low-cost invertebrate model.
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Ethnopharmacological Relevance: Paffia spp (Amaranthacea) has a widespread use of in Brazil as a possible hormonal supplement and a substitute of Panax ginseng, although information on its reproductive effects is missing.

Aim Of The Study: To evaluated possible anabolic-androgenic or anti-androgenic effects of Pfaffia glomerata (PG) extract using intact eight-months-old male rats and pre-pubertal castrated rats.

Materials And Methods: Three different dose levels of PG (8.

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Objectives: The aim of this study was to evaluate the flavonoid content of an ethanolic leaf extract from the medicinal plant Rourea induta Planch. (RIEE) and to investigate its hepatoprotective potential and in vivo antioxidant effects.

Methods: Using samples from carbon tetrachloride-treated Wistar female rats treated orally with or without RIEE, we evaluated the aspartate aminotransferase, alanine aminotransferase, and total bilirubin levels in plasma; the levels of the hepatic oxidative stress markers catalase, superoxide dismutase, glutathione peroxidase, and reduced glutathione in liver homogenates; and the thiobarbituric acid reactive substance levels.

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Ethnopharmacological Relevance: Rourea induta Planch. is a small tree or shrub growing wild in Brazil and belonging to the Connaraceae family. It is used for the treatment of Chagas disease and as antirheumatic in folk medicine.

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Data on in vitro evaluation of extracts of three species of the Asteraceae family on the development of Trichostrongylidae eggs in sheep are presented. Egg hatchability was tested using herbal extracts prepared in a Soxhlet extractor, and using hydrolate prepared by means of hydrodistillation. The laboratory tests showed that the ethanol extract from flowers of the species Aster lanceolatus presented high activity against Trichostrongylidae eggs development in sheep, inhibiting larva formation by 91% within 48 hours, and maintaining similar rates after 72 hours.

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