(PhSe) and (Cl-PhSe) organochalcogen compounds inhibit adhesion to human endocervical (HeLa) cells and show anti-biofilm activities.

Adhesion capacity on biological surfaces and biofilm formation is considered an important step in the infection process by The ability of (PhSe) and (Cl-PhSe), two synthetic organic selenium (organochalcogen) compounds, to act on virulence factors related to adhesion to human endocervical (HeLa) cell surfaces and their anti-biofilm activities was analyzed. Both organochalcogen compounds inhibited adhesion to HeLa cells, dependent on compound concentrations. (PhSe) (at 20 µM;  = 0.