Publications by authors named "Marilia S Costa"

Background: Weeds reduce crop yields, and among the methods used to control these plants, the use of chemicals is preferred. However, the repeated application of herbicides with the same mechanism of action selects for resistant populations. The aim of this study was to evaluate glyphosate resistance in Lolium multiflorum (Lam.

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The purpose of this study was to prepare various 4-substituted N-phenyl-1,2,3-triazole derivatives using click chemistry. The derivatives were screened in vitro for antimicrobial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294) using the Alamar Blue susceptibility test. The activity was expressed as the minimum inhibitory concentration (MIC) in μg/mL (μM).

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Several compounds of great pharmacological interest contain the triazole and imidazole rings. In order to find new drugs with antileishmanial activity we have synthesized and evaluated new imidazole and triazole compounds carrying either the carbaldehyde or the difluoromethylene functionalities against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly.

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The adenomatoid odontogenic tumor (AOT) is a benign, non-invasive lesion with a slow but progressive growth. This tumor has three variants: follicular, extrafollicular, and peripheral. The extrafollicular type is an intraosseous lesion that is not associated with unerupted teeth.

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The molecules of ethyl 5-amino-1-(4-cyanophenyl)-1H-imidazole-4-carboxylate, C13H12N4O2, are linked into a chain of alternating R(2)2(10) and R(4)4(34) rings by a combination of N-H...

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Article Synopsis
  • The study focused on creating and testing new compounds called N-substituted-phenyl-1,2,3-triazole-4-carbaldehydes (3a-l) for their effectiveness against Mycobacterium tuberculosis.
  • The compounds were synthesized through reactions of aromatic amines and showed promising anti-tubercular activity, especially compounds 3a and 3k, which had similar effectiveness to existing tuberculosis drugs.
  • A structure-activity relationship (SAR) analysis revealed that factors like the presence of hydrogen bond acceptors and the arrangement of aromatic rings significantly impacted the compounds' anti-tubercular properties, highlighting 3a and 3k as potential candidates for future research.
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