Bioactive small molecules produced by the human gut microbiome modulate sessile and planktonic lifestyles.

Humans live in symbiosis with a diverse community of microorganisms, which has evolved to carry out many specific tasks that benefit the host, including protection against invading pathogens. Within the chemical diversity of the gastrointestinal tract, small molecules likely constitute chemical cues for the communication between the microbiota and pathogens. Therefore, we sought to investigate if molecules produced by the human gut microbiota show biological activity against the human pathogen .

Small Molecules Produced by Commensal Staphylococcus epidermidis Disrupt Formation of Biofilms by Staphylococcus aureus.

The microbiota influences host health through several mechanisms, including protecting it from pathogen colonization. is one of the most frequently found species in the skin microbiota, and its presence can limit the development of pathogens such as causes diverse types of infections ranging from skin abscesses to bloodstream infections. Given the increasing prevalence of drug-resistant strains, it is imperative to search for new strategies for treatment and prevention.