Evaluation of Novel Chalcone-Thiosemicarbazones Derivatives as Potential Anti- Agents and Its HSA Binding Studies.

A series of seven chalcone-thiosemicarbazones (-) were synthesized and evaluated as potential new drugs (anti-leishmanial effect). Although four of the chalcone-thiosemicarbazones are already known, none of them or any compound in this class has been previously investigated for their effects on parasites of the genus. The compounds were prepared in satisfactory yields (40-75%) and these compounds were evaluated against promastigotes, axenic amastigotes and intracellular amastigotes of after 48 h of culture.