Publications by authors named "Marilena Lucarelli"
Article Synopsis
- The study investigates the relationship between somatic DNA damage and coronary artery disease (CAD) in a large group of patients undergoing coronary angiography, using the micronucleus assay to assess DNA damage levels.
- Among 278 patients, significant CAD was identified in 210, with patients showing multivessel disease exhibiting the highest levels of DNA damage (measured by micronuclei frequency).
- Results suggest that type 2 diabetes and nitrate therapy are key factors associated with increased DNA damage in CAD patients, indicating potential for DNA damage as a therapeutic target in diabetes-related coronary artery disease management.
Nano-sized particles of ceramic and metallic materials are generated by high-tech industrial activities, and can be generated from worn-out replacement and prosthetic implants. The interaction with the human body of such nanoparticles has been investigated, with a particular emphasis on innate defence mechanisms. Human macrophages (PMA-differentiated myelomonocytic U-937 cells) were exposed in vitro to non-toxic concentrations of TiO(2), SiO(2), ZrO(2), or Co nanoparticles, and their inflammatory response (expression of TLR receptors and co-receptors, and cytokine production) was examined.
View Article and Find Full Text PDFThe human chemokine CCL2 gene was expressed in the yeast P.pastoris and gave rise to a mixture of differently glycosylated recombinant proteins. In comparison to non-glycosylated E.
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