Effect of MCI-9042, a 5-HT2 receptor antagonist, on retinal ganglion cell death and retinal ischemia.

The neuroprotective effect of MCI-9042 (Mitsubishi Pharma Corporation) was investigated on glutamate-induced retinal ganglion cell (RGC) death in vitro and on rat retinal ischemia in vivo. RGCs were purified from retinal cells isolated from 6-day-old Wistar rats and cultured in serum-free media. After application of 25 microM glutamate, the viability of RGCs treated with or without several serotonin 2 (5-HT(2)) receptor antagonists: MCI-9042, M-1 (a major metabolite of MCI-9042), ketanserin, and LY-53857; was evaluated by calcein-acetoxymethyl ester staining.

Protective action of nipradilol against ischemia-induced retinal damage in rats.

The purpose of this study was to investigate whether nipradilol, a beta-blocker having both vasodilating and alpha(1)-blocking activities, can protect retinal cells from the injury induced by ischemia and reperfusion. Rats were anesthetized and, after an intravitreal injection of nipradilol, the intraocular pressure was raised for 45 min to induce retinal ischemia and reperfusion. Before, and 3 and 7 days after the ischemia, electroretinograms were recorded.

Binocular interaction reflected in visually evoked cortical potentials as studied with pseudorandom stimuli.

Purpose: To study the interaction of visual signals from both eyes with visual evoked cortical potentials (VECPs) elicited by pseudorandom binary sequence (PRBS) stimuli.

Methods: A PRBS was used to drive two independent LED arrays to elicit VECPs. The right and left eyes were simultaneously stimulated by two different series of PRBS stimuli.

Anterior ischemic optic neuropathy associated with idiopathic aldosteronism and hypertension.

A 49-year-old man suffered from bilateral anterior ischemic optic neuropathy almost simultaneously, and was diagnosed with idiopathic aldosteronism associated with hypertension. Because this patient had multiple organ disorders, multiple cerebral infarctions, and a mild loss of renal function, it was important to treat his primary disease.