Publications by authors named "Mariko Takana-Ishikawa"
J Am Heart Assoc
April 2021
Article Synopsis
- Recent research indicates that toll-like receptor 9 (TLR9) plays a role in cardiovascular diseases, but its impact on pulmonary hypertension is still unclear; this study hypothesizes TLR9's involvement in pulmonary hypertension development.
- In a rat model, it was found that TLR9 activation boosts the severity of pulmonary hypertension, linked to increased right ventricular pressure and vascular changes, alongside macrophage accumulation following monocrotaline exposure.
- Using TLR9 inhibitors significantly improved these conditions, suggesting that targeting TLR9 could offer a promising new treatment strategy for pulmonary hypertension by disrupting the NF-κB‒IL-6 signaling pathway.
