Publications by authors named "Mariko Nakamura-Higa"
Article Synopsis
- Class I HDAC inhibitors may enhance neurite growth, synaptic plasticity, and neurogenesis in the adult brain, but their specific molecular targets are not well understood.
- A study using microarrays discovered that tescalcin (Tesc) is significantly up-regulated in neurons treated with these inhibitors.
- Overexpression of TESC in hippocampal neurons led to a more than 5-fold increase in neurite length and branching, suggesting TESC's important role in neuroprotection and potential involvement in brain and neurodegenerative disease development.