Publications by authors named "Mariko Minami"

Background: Posterior reversible encephalopathy syndrome (PRES) is known as a transfusion-related complication with typically favorable prognosis and no report fatalities. Pathological evaluation of PRES is also scarce.

Case Report: An 88-year-old female with myelodysplastic syndromes (MDS) attended our hospital because of a compression fracture and chronic heart failure with chronic anemia.

View Article and Find Full Text PDF

Infection is a major contributor to non-relapse mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Detecting infectious diseases in febrile patients during pretransplant conditioning is crucial for subsequent transplant success. Procalcitonin (PCT) is an auxiliary diagnostic marker of severe bacterial infections and has been proposed as a useful predictor of infection in patients undergoing allo-HSCT.

View Article and Find Full Text PDF
Article Synopsis
  • * Congenital thrombotic thrombocytopenic purpura (cTTP) was suspected, prompting tests for ADAMTS13 activity, which revealed severely decreased activity but no inhibitors present.
  • * The combination of test results and genetic testing in her family confirmed a diagnosis of cTTP, highlighting the need for careful evaluation of ITP patients for potential cTTP during follow-up.
View Article and Find Full Text PDF
Article Synopsis
  • * Initial tests for leukemia-related chimeric genes were negative, but karyotyping revealed an inversion in chromosome 16, which led to further analysis confirming the CBFB::MYH11 fusion gene through advanced techniques like FISH and RNA sequencing.
  • * This case demonstrates a rare subtype of the CBFB::MYH11 fusion gene that can result in false-negative findings with standard screening, highlighting the importance of using modified PCR primers, FISH, and RNA sequencing for accurate diagnosis.
View Article and Find Full Text PDF

Objective: We sought to assess the safety and feasibility of outpatient management in Japanese patients with relapsed/refractory lymphoma who had received pegfilgrastim after salvage therapy.

Method: This was a single-center, open-label, non-randomized, prospective interventional analysis. Patients were completely hospitalized for cycle 1 of chemotherapy.

View Article and Find Full Text PDF

Hematologic diseases frequently affect people >60 years old, and allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for these patients. Although several multicenter studies proposed the risk assessment of allo-SCT for the elderly, they receive different treatments and management at each facility. Therefore, accumulating data from institutions that exhibit relatively the same treatment policy and patient care is important.

View Article and Find Full Text PDF
Article Synopsis
  • A new endoscopic gastric cancer screening program was initiated in Kurashiki city, focusing on infection status based on endoscopic features, to evaluate its feasibility in a prospective study involving 1784 participants.
  • The study found that 68.1% of subjects showed no gastritis, while 26.3% had active or inactive gastritis, with an endoscopic false-negative rate of 16.3% when compared to a serum test method.
  • Although endoscopic assessments are generally reliable, the presence of mild gastric atrophy may lead to false negatives, prompting researchers to suggest incorporating antibody tests to improve diagnostic accuracy.
View Article and Find Full Text PDF

Purpose: Comprehensive geriatric assessment (CGA) has been used to help identify elderly patients with diffuse large B-cell lymphoma (DLBCL) who were suitable for rituximab combined with CHOP therapy (cyclophosphamide, Adriamycin, vincristine, and prednisolone), but there are few reports of CGA for elderly patients with DLBCL who received R-mini-CHOP.

Methods: We retrospectively analyzed the risk factors for outcomes among 142 patients aged 80 years and older (≤ 85 years, n = 102; > 85 years, n = 40) with DLBCL who received R-mini-CHOP at 4-week intervals at our institute between 2008 and 2019. We performed a comparison between CGA and treatment outcomes.

View Article and Find Full Text PDF

Background And Aim: Duodenal ulcer bleeding has a higher risk of mortality than bleeding from other portions of the gastrointestinal tract. AIMS65 is an effective risk-scoring system to predict prognosis of upper gastrointestinal bleeding and can be easily calculated without endoscopic findings. In this study, we investigate the usefulness of AIMS65 to predict prognosis of patients with duodenal ulcer bleeding.

View Article and Find Full Text PDF

In the original publication of the article, the "CNS involvement" in the last row under the column "Total N=50" has been published incorrectly. The correct Table 1 is given in this correction.

View Article and Find Full Text PDF

We stratified patients with newly diagnosed acute promyelocytic leukemia (APL) according to a white blood cell (WBC) count of ≥ 3 × 10/L (high risk) or < 3 × 10/L (low risk) before administering risk-adapted chemotherapy in combination with all-trans retinoic acid (ATRA). In total, 27 low-risk and 23 high-risk patients were assigned to receive induction and three courses of consolidation with ATRA and anthracycline, followed by 2-year maintenance regimen. High-risk group additionally received cytarabine during 1st consolidation and another one-shot idarubicin treatment during 3rd consolidation.

View Article and Find Full Text PDF

To elucidate dynamic changes in native BCR-ABL and alternatively spliced tyrosine kinase inhibitor (TKI)-resistant but function-dead BCR-ABL variant, following commencement or discontinuation of TKI therapy, each transcript was serially quantified in patients with chronic myeloid leukemia (CML) by deep sequencing. Because both transcripts were amplified together using conventional PCR system for measuring International Scale (IS), deep sequencing method was used for quantifying such BCR-ABL variants. At the initial diagnosis, 7 of 9 patients presented a small fraction of cells possessing BCR-ABL , accounting for 0.

View Article and Find Full Text PDF

Classic hairy cell leukemia (classic HCL) is a rare disease associated with indolent mature B-cell lymphoma. A 50-year-old man presented with pancytopenia for 3 years and was diagnosed with classic HCL because his lymphoid cells showed a hairy morphology with oval nuclei and indistinct nucleoli both in the peripheral blood and bone marrow (BM) smears. Flow cytometric analysis revealed that these cells expressed CD11c, CD25, and CD103, and the Sanger sequence method detected BRAF V600E mutation.

View Article and Find Full Text PDF

We present the case of a 56-year-old man with an upper respiratory infection followed by fatigue, hypotension, and hyponatremia. Bilateral adrenal hemorrhage was confirmed, based on T2-weighted magnetic resonance imaging. The patient had previously undergone allogeneic hematopoietic stem cell transplantation and had been diagnosed with antiphospholipid syndrome (APS) during the development of chronic graft-versus-host disease.

View Article and Find Full Text PDF

Pulmonary hypertension (PH) is a rare, but life-threatening, adverse event in patients treated with tyrosine kinase inhibitors (TKIs), such as dasatinib, but has not been fully evaluated in patients treated with imatinib or nilotinib. We used echocardiography to noninvasively assess the incidence of PH in 105 patients with chronic myeloid leukaemia (CML) treated with imatinib (n = 37), nilotinib (n = 30) or dasatinib (n = 38). The mean triscupid regurgitation peak gradient (TRPG), which reflects pulmonary arterial pressure, was 22·7 mmHg in the imatinib group, 23·1 mmHg in the nilotinib group and 23·4 mmHg for dasatinib group.

View Article and Find Full Text PDF
Article Synopsis
  • Langerhans cell histiocytosis (LCH) is a rare disease in adults, and its treatment strategies are still being debated, particularly for the aggressive multiple system form (MS-LCH).
  • Intensive systemic chemotherapy has proven effective in improving outcomes for pediatric patients with MS-LCH, raising questions about its applicability to adults.
  • This report highlights two adult cases where intensified chemotherapy protocols, similar to those used for children, led to successful treatment outcomes, including a two-year complete response for one patient.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session6im4da83v3jms27d9s78ctbl5q6veq79): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once