Synopsis of recent research by authors named "Mariko Kotono"
- Mariko Kotono's recent research investigates the mechanisms of resistance to enfortumab vedotin in urothelial cancer, particularly focusing on the role of ATP-binding cassette (ABC) transporters.
- The study presents a case involving a 76-year-old male patient with metastatic bladder cancer who showed disease progression despite treatment with enfortumab vedotin, highlighting the clinical implications of resistance mechanisms.
- Findings suggest that along with decreased nectin-4 expression, the upregulation of ABC transporters may contribute significantly to resistance against enfortumab vedotin, indicating potential targets for improving therapeutic outcomes.
