Publications by authors named "Mariko Kajiwara"
Article Synopsis
- * Research with mice and cultured cells shows that Uro A increases mucin 2 expression and thickens colonic mucus without affecting tight junctions, which are crucial for maintaining barrier integrity.
- * Uro A treatment also reduces gut permeability and inflammation, promotes beneficial bacteria, and works through specific signaling pathways (Nrf2 and AhR) to enhance mucus secretion and support intestinal health.
Background And Aims: Free D-amino acids, which have different functions from L-amino acids, have recently been discovered in various tissues. However, studies on the potential interactions between intestinal inflammation and D-amino acids are limited. We examined the inhibitory effects of D-alanine on the pathogenesis of intestinal inflammation.
View Article and Find Full Text PDFBackground: Recent progress in ulcerative colitis (UC) treatment has been remarkable, and various medications have been applied. However, some patients with UC are refractory to treatment and convert to surgery.
Aim: To investigate the role of colonic mucosal Wnt-5a expression in the pathogenesis of UC and the effect of bioactive Wnt-5a peptide on colitis in mice.
Article Synopsis
- The study investigates the relationship between mucosal cytokine levels and clinical relapse in ulcerative colitis patients who initially presented with complete mucosal healing (Mayo endoscopic subscore of 0).
- A total of 55 patients were enrolled, and their rectal mucosa was analyzed for various cytokines to determine which might predict relapses.
- Results showed that several cytokines, especially interleukin-8, were significantly elevated in patients who experienced relapse, indicating its potential as a predictor for future clinical issues.
We report the case of a 36‒year‒old man who was treated with S‒1 plus oxaliplatin(SOX)therapy for gastric cancer with disseminated intravascular coagulation(DIC). The patient visited our hospital for the treatment of an unresectable type 4 advanced gastric cancer. He had respiratory distress at the first visit.
View Article and Find Full Text PDF