Synopsis of recent research by authors named "Mariko Deguchi"
Mariko Deguchi's research primarily focuses on the pharmacogenomics and pharmacokinetics of various drugs, particularly in relation to genetic polymorphisms and their impact on drug metabolism and efficacy in treating conditions such as epilepsy and cardiovascular diseases.
Her studies highlight the role of specific biomarkers, like exosomal miR-328 and superoxide dismutase 2 polymorphisms, in predicting drug response and assessing potential risks associated with medications like valproic acid and clopidogrel.
Deguchi employs various methodologies, including population-based pharmacokinetic-pharmacodynamic analyses and microdosing strategies, to explore drug interactions and optimize treatment regimens tailored to individual genetic profiles.
