Safety of vancomycin in patients with moderate and severe renal dysfunction.

Aim: The new guidelines in Japan do not recommend a vancomycin (VCM) loading dose for patients with an estimated glomerular filtration rate (eGFR) 30 < and ≤ 80 mL×min×1.73m (moderate renal dysfunction) or administration to those with the eGFR < 30 mL×min×1.73m (severe renal dysfunction).