Publications by authors named "Marike van Lingen"
9-HODE associates with thalamic atrophy and predicts white matter damage in multiple sclerosis.
Mult Scler Relat Disord
December 2024
Background: Multiple sclerosis (MS) is characterized by extensive tissue damage leading to a range of complex symptoms, including physical disability and cognitive dysfunction. Recent work has indicated the clinical relevance of bioactive lipid mediators (LMs), which are known to orchestrate inflammation and its resolution and are deregulated in MS. However, it is unknown whether LM profiles relate to white matter (WM) damage.
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- Glioma is linked to increased brain activity around tumors, which contributes to faster disease progression and changes in how different brain regions communicate, affecting symptoms.
- The study analyzed brain activity and connectivity in 84 glioma patients and compared it to 61 healthy individuals, focusing on the power spectrum and network connectivity measures like clustering coefficient and eigenvector centrality.
- Findings showed that while tumor-related activity was high in patients, it corresponded to low connectivity in their brain networks, suggesting a complicated relationship between tumor activity and brain function, which could impact how the disease and its symptoms develop.
Cognitive impairment occurs in 40-65% of persons with multiple sclerosis and may be related to alterations in glutamatergic and GABAergic neurotransmission. Therefore, the aim of this study was to determine how glutamatergic and GABAergic changes relate to cognitive functioning in multiple sclerosis . Sixty persons with multiple sclerosis (mean age 45.
View Article and Find Full Text PDFMany patients with glioma, primary brain tumors, suffer from poorly understood executive functioning deficits before and/or after tumor resection. We aimed to test whether frontoparietal network centrality of multilayer networks, allowing for integration across multiple frequencies, relates to and predicts executive functioning in glioma. Patients with glioma (n = 37) underwent resting-state magnetoencephalography and neuropsychological tests assessing word fluency, inhibition, and set shifting before (T1) and one year after tumor resection (T2).
View Article and Find Full Text PDFSerotonin (5-HT) is a crucial signal in the neurogenic niche microenvironment. Dysregulation of the 5-HT system leads to mood disorders but also to changes in appetite and metabolic rate. Tryptophan hydroxylase 2-deficient ( ) mice depleted of brain 5-HT display alterations in these parameters, e.
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