Publications by authors named "Marika S Saarela"
The brain-derived neurotrophic factor (BDNF) promotes survival, differentiation and maintenance of neurons in the central nervous system. BDNF 196 G>A and 270 C>T polymorphisms have previously been associated with Alzheimer's disease (AD) and with Parkinson's disease (PD). To study the role of BDNF 196 G>A and 270 C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196 G>A and 270 C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction.
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- Polymorphisms in matrix metalloproteinases (MMPs), specifically MMP1 and MMP3, are linked to Alzheimer's and Parkinson's diseases, with MMP1 and MMP3 levels elevated in affected brain tissues.
- A study involving 97 Alzheimer's and 52 Parkinson's patients, along with 101 controls, examined the relationship between MMP1 and MMP3 genetic variations and disease risk.
- Results indicated a significant interaction between the MMP3*5A polymorphism and APOE 4 allele, markedly increasing Alzheimer's risk, suggesting that MMP3 might play a role in disease development.