Publications by authors named "Marika Pinto"
Background: Typhoid and paratyphoid fevers represent a global health burden, especially in Southern Asia, exacerbated by the increase in antimicrobial resistance. While vaccines against Typhi have been successfully introduced, a vaccine against Paratyphi A is not available, yet. Efforts to develop an effective vaccine targeting both serovars are currently ongoing.
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- Shigellosis is a serious health issue, especially for children under 5 in low- and middle-income countries, and is linked to growth problems and antibiotic resistance.
- There is an urgent need for a broad-spectrum vaccine, with current research focusing on the role of anti-O-Antigen-specific IgG and verifying its functionality using a new high-throughput luminescence-based Serum Bactericidal Assay (L-SBA).
- This study successfully refined the L-SBA to assess multiple Shigella serotypes, confirming its effectiveness and precision, which can help in understanding natural immune responses and testing vaccine efficacy.
The reduction of aromatic nitro compounds has been performed employing a catalytic amount of Wang resin-supported phenyl(2-quinolyl)methanol (Wang-PQM) in the presence of an excess of NaBH to regenerate the reactive reducing species at the end of the process. The reduction products are easily isolated through a simple filtration/extraction protocol, and the catalyst can be efficiently recovered and recycled. The condensation route is generally preferred, and azo- and/or hydrazo-arenes can be easily prepared in high yields.
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